Roma is the custodian of numerous valuable works by Michelangelo Merisi da Caravaggio, they can be found in palaces, the houses of noble families, churches, galleries and museums. The itinery for discovering the masterpieces of the great artist winds between Piazza Venezia, Piazza del Popolo, and the area near to the green expanse of Villa Borghese and the Vatican City.

The Borghese gallery possesses no less than six of the master's works, this is the world's greatest collection: they are "Giovane con la canestra di frutta", "Bacchino malato", "San Girolamo", "Madonna dei Palafrenieri", "Davide con la testa di Golia" and finally "San Giovannino". "San Francesco in meditazione" in the church of the Cappuccini Convento on Via Veneto is also attributed to Caravaggio, while the mythical "Narciso" and the "Decapitazione di Oloferne" are in the Galleria Nazionale d'Arte Antica di Palazzo Barberini.

Just a short walk from Piazza Venezia in the Galleria Doria Pamphilj on Piazza del Collegio Romano visitators can see the splendid "Riposo dalla fuga in Egitto", "Maddalena" and "San Giovanni Battista". Other masterpieces by the great Lombard artist can be found in the Corsini Galleria on Via della Lungara ("San Giovanni Battista nel Deserto"), in the Vatican Museum ("Deposizione di Cristo"), in the church of Santa Maria del Popolo in Piazza del Popolo ("Converzione di San Paolo" and the "Crocefissione di San Pietro"); in Sant'Agostino on Via della Scrofa ("Madonna dei Pellegrini"). Finally in San Luigi dei Francesi on the piazza of the same name there is a series of paintings which tell the story of Saint Matthew in the Cappella Contarelli of the church, they are: "Vocazione", "Il Martirio", and "San Matteo e l'Angelo". In the Casino Ludovisi, the last remains of the Villa Ludovisi on Via Lombardia, Caravaggio created frescos in oil on the walls of the alchemy laboratory, painting "Giove, Nettuno and Plutone" in triumph around the sun.